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Midwest Computational Structural Biology Workshop

Table of Contents

Talks - Saturday, April 30

Afternoon Session Page
Protein Networks for Structural and Functional Protein Behavior by Robert Jernigan 1
Experimental and Computational Dynamics of Proteins in Crystals by George Phillips 2
Computational Analysis of the Assumptions Underlying Use of FRET as a Spectroscopic Rulerby Brent Krueger 3
An Automatic Method for Identifying Reaction Coordinates in Complex Systems by Ao Ma 4
Normal Mode Analysis of Domain Motions of S-Adenosylhomocysteine Hydrolase by Krzysztof Kuczera 5
Controlling Entropy: The Key to Protein Design by Garland Marshall 6
Computational Protocols for Functional Annotations of Proteins by Jarek Meller 7
A Framework for Globular Proteins by Jayanth Banavar 8
Recognizing Protein Folds by Cluster Distance Geometry by Gordon Crippen 9
Modeling Proteins in the Unfolded State by Karl Freed 10
Silico Folding of Small Proteins by Ulrich Hansmann 11
Structural Bioinformatics Prediction of Transcription Factors and Target Sites by Hui Lun 12
Interplay of Computation and Experiment in Studies of Microbial Pathogenesis: the Type II and Type III Secretion Mechanisms of Gram-negative Bacteria by William Wedemeyer 13

Talks - Sunday, May 1

Morning Session Page
A Molecular Dynamics Study of Water Chain Formation in the Proton-Conducting K Channel of Cytochrome C Oxidase by Robert Cukier 14
Continuum Modelling of Biomolecular Electrostatics and Diffusion by Nathan Baker 15
Efficient Simulatio of Biomolecules with Implicit Solvent by Michael Feig 16
Properties of Polyunsaturated Lipids from MD Simulation by Scott Feller 17
The Iteratively Matched Interface (IMI) Fast Poisson Solver for the Prediction of Membrane Protein Structures by Guowei Wei 18
Toward Developing New Scoring Functions for Structure-Based Drug Design by Shaomeng Wang 19
Computer Simulation of the Pharmacophore Profiles for d-Opioid Receptor Selective Peptide Agonists by Paul Smith 20
A Hierarchical Model for Designing Protein Kinase Inhibitors by Chung Wong 21
Enrichment Enhancement in High Throughput Structure-based Virtual Screening through a Combination of FRED, ROCS, EON Scores and Naďve Bayesian Classification by Lakshmi Narasimhan 22
Catch Me If You Can: A New View of the Dynamical Mechanism of Protein-protein Recognition by Carlos Camacho 23
Protein Dynamics in the Catalysis by 6-Hydroxymethyl-7,8-dihydropterin Pyrophophokinase by Honggao Yan 24
Voxelized Protein Model for Fast Protein Docking and Function Prediction by Daisuke Kihara 25
Modeling Flexibility in Molecular Recognition by Maria Zavodszky 26

 

Posters

1. Using Difference Refinement to Fit Myoglobin Coordinates from Time-resolved X-ray Crystallographic Data by Aranda IV, Roman, Levin, Elena J. 27
2. Using Low Complexity Regions for Target Selection in Structural Genomics by Bannen, Ryan M. 28
3. Simulating Nucleic Acids: Comparison Between Explicit, Implicit and Hybrid Solvation Models by Chocholoušová, Jana 29
4. Folding Proteins by Constrained Minimization of a Statistical Potential of Mean Force by Colubri, Andrés 30
5. Effect of Sequence Length and Number of Taxa on Phylogeny SimDB: The Simulation Database by Connelly, Brian 31
6. A Model for Binding of Capping Protein to Barbed End of Actin by Ghosh, Shatadal 32
7. Rapid Computational Prediction of the Substrates of cAMP-dependent Protein Kinaseby Haenfler, Jill 33
8. Molecular Dynamics Simulations of Phospholamban: Effects of Membrane, Phosphorylation and Aggregation. by Houndonougbo, Yao 34
9. Predisposition of the Three-Dimensional Dark State Structure of Rhodopsin for Functional Conformational Changes by Isin, Basak 35
10. The “other half” of the Folded State of Proteins by Jha, Abhishek 36
11. Identifying Favourable Candidate Molecules Using Statistical Physics by Jones, Andrew 37
12. Finding Alternate Binding Conformations in Proteins: A Molecular Dynamics and Docking Study of p38 MAP Kinase by Kesner, Tamara Frembgen 38
13. Protein Structure-Sequence Alignment with a Reliability Measure by Kihara, Daisuke 39
14. Mechanism of Control of Small Ligand Release in Nitrophorin and Myoglobin by Kondrashov, Dmitry A. 40
15. Using Difference Refinement to Fit Myoglobin Coordinates from Time-resolved X-ray Crystallographic Databy Levin, Elena and Aranda IV, Roman 41
16. A Molecular Dynamics Free Energy Study of the Large-scale Motion of Adenylate Kinase by Lou, Hongfeng 42
17. Application of Rough Set Theory to the Analysis of Chemically-Induced Gene Expression Patterns by Maggiora, Gerry 43
18. Atomically Detailed Simulations of Concentrated Protein Solutions: Capturing the Effects of pH, Ionic Strength and Point Mutations by McGuffee, Sean R. 44
19. Binding of Dinitroanilines to a-Tubulin of Protozoan Parasites via Computational Modeling by Mitra, Arpita 45
20. Characterization of Internal and Global Dynamics of HIV-1 TAR RNA by Molecular Dynamics and NMR by Musselman, Catherine 46
21. An Efficient Iterative Cost-Bounded Branch-and-Bound Search Algorithm for Solving Discrete Optimization Problems in Computational Biology by Namilikonda, Sandeep K 47
22. Effect of Domain-domain Interactions on Src Family Tyrosine Kinase Activation by Ozkirimli, Elif 48
23. Structural Insights into Mechanism of Actin based Cell Motility Via Computational Modeling by Rammohan, Aravind R. 49
24. Rapid Computational Identification of the Targets of Protein Kinase Inhibit by Rockey, William M. 50
25. Human Topoisomerase I Relaxes Positive and Negative DNA Supercoils Differently by Sari, Levent 51
26. Molecular Dynamic Simulations of the Wild Type and Mutant (D25N) HIV Protease: Insights into Enzyme Activity and Drug Resistance by Seibold, Steve A. 52
27. A Multiscale Model for Actin Filaments by Sept, David 53
28. Structural Determinants of Brugia malayi Asparaginyl tRNA Synthetase Affinity and Specificity for Inhibitors Discovered by Structure-Based Screening by Sukuru, Sai Chetan K. 54
29. Free Energy of G76 and the Mutants Rotation in Hepatitis Delta Virus Ribozyme by Sun, Juan 55
30. Replica Exchange Molecular Dynamics Simulations Coupled with the Heterogeneous Dielectric Generalized Born Model: Helix Association by Tanizaki, Seiichiro 56
31. Molecular Dynamics Simulations of Salt on Small Molecule Associations: Effects on Electrostatic and Hydrophobic Interactions and Comparison with Implicit Models by Thomas, Andrew S. 57
32. Repetitive Pulling Catalyzes Co-Translocational Unfolding of Barnase During Import Through a Mitochondria Pore by Tian, Pu 58
33. New Developments in Empirical Scoring Function: X-Score Version 2005 by Wang, Renxiao 59
34. The PDBbind Database: A PDB-Wide Collection of Protein-Ligand Binding Affinities by Wang, Renxiao 60
35. Functional Importance of Protein Dynamics in Enthalpy-Entropy Compensation by Ward, Joshua 61
36. SoftScore: A New Knowledge-Based Potential Scoring Function by Inclusion of the Mobility of Protein Atoms by Yang, Chao-Yie 62
37. A Molecular Dynamics Exploration of Dihydroneopterin Aldolase and the Exit Path of its Product-bound Form by Yao, Lishan 63

Participant List